A new piece added to the puzzle describing the natural history of Whipple disease. A, Interhuman transmission likely takes place through fecaloral contamination. However, infection might also possibly follow exposure to human saliva and/or aerosols or be associated with yet unknown environmental or zoonotic risks. B, Primary infection might be asymptomatic but may also present as a febrile illness associated with cough and sleep disorders, as demonstrated by Fenollar et al. in this issue