CONCLUSIONS:
Oral health care professionals should be aware of the importance of recognizing oral manifestations of systemic
diseases. The dentist, and mainly the periodontists and oral
pathologist, plays a fundamental role in the early diagnosis
of leukemia knowing that the first symptoms of the disease
occur in the oral cavity with normal or show subtle changes
in initial laboratory tests. It is essential for the professional
to be able to clearly recognize oral physiological
characteristics, and, when identifying a change of normalcy,
to fully investigate it requesting additional tests or referring
the patient to specialized professional.