In summary, our data of electrophysiological study provides enough
evidence for visual cortex hyper-excitability in migraine with and
without aura. Furthermore, in therapeutic study, inhibitory tDCS over
the occipital cortex was effective for migraine prophylaxis with regard
(i) to reduce the painkiller intake, when compared with sham stimulation
and (ii) to decrease the number of migraine attacks and average
duration of each migraine attack, when compared to baseline condition,
but unable to normalize the abnormal cortical hyper-excitability. It
suggests that the excitability level of visual cortex neurons in migraine
cannot drive appropriate brain stimulation protocol. These results
should be replicated and confirmed with wider samples before being
considered in clinical decision making