The market price of our common shares is subject to fluctuations in response to variations in our quarterly
operating results, general trends in the market for our products and product candidates, economic and currency
exchange issues in the foreign markets in which we operate as well as other factors, many of which are not within
our control. In addition, broad market fluctuations, as well as general economic, business and political conditions
may adversely affect the market for our common shares, regardless of our actual or projected performance.
The closing price of our common shares on February 18, 2015, was $33.42. The approximate number of
holders of record of our common shares as of February 18, 2015 was 671. This number of holders of record does
not represent the actual number of beneficial owners of our common shares because shares are frequently held in
“street name” by securities dealers and others for the benefit of individual owners who have the right to vote their
shares.