47. There is no data on the toxicity of P. ostreatus hemolysins in oyster mushroom consumers. Oyster mushroom is considered a non-toxic mushroom and the presence of hemolysins does not influence this conclusion. Hemolysins are thermo-labile, and potential toxicity would be considered only for raw mushrooms. Furthermore, proteins are usually degraded in the gastrointestinal tract when ingested. Administration of aqueous extracts of P. ostreatus to mice demonstrated no acute effects (Al-Deen et al., 1987; Bedry et al., 2001) and repeated oral feeding of the mushroom to rodents revealed no histopathological changes of cardiac or hepatic tissue (Bobek et al., 1998; Nieminen et al., 2009).