The outlook for development of scientific-grade instrumentation utilizing the FOSS approach is extremely promising. Inexpensive open-source 3-D printers and free software have put one-off production of highly specialized tools within the grasp of the end user, bypassing historically expensive design and manufacturing steps. Perhaps more importantly, these technologies and methodologies promise heretofore unheard of access to sophisticated instrumentation by those most in need of it, under-developed and developing world laboratories.