A reduction in the time to first plasma transfusion during DCR significantly reduces mortality. However, fresh frozen plasma (FFP) and FP24 require up to 60–75 min preparation that significantly delays plasma availability. In contrast, stored thawed plasma, which retains acceptable levels of all coagulation factors for up to 5 days can be transfused immediately. Immediate transfusion of plasma is associated with an overall reduction in the amount of plasma and other blood components transfused during DCR and with reduced plasma wastage. Also, plasma separated from whole blood and stored at 4 °C for 21 days, and referred to as liquid plasma, retains close to 90% coagulation factor activity, and is the primary source of plasma in many European DCR strategies. Reconstituted lyophilized plasma (LP) is another source of this blood component that may be used immediately for a recipient of any blood type because of dilution and neutralization of anti-A and anti-B hemagglutinins. LP, which contains coagulation factor levels equivalent to FFP, has been used by the French Army since 1994. Presently, LP is utilized by medics of the Israeli Defense Force for resuscitation of combat casualties in hemorrhagic shock, and previously LP was carried for a similar purpose by U.S. Special Operations Forces in Afghanistan
A reduction in the time to first plasma transfusion during DCR significantly reduces mortality. However, fresh frozen plasma (FFP) and FP24 require up to 60–75 min preparation that significantly delays plasma availability. In contrast, stored thawed plasma, which retains acceptable levels of all coagulation factors for up to 5 days can be transfused immediately. Immediate transfusion of plasma is associated with an overall reduction in the amount of plasma and other blood components transfused during DCR and with reduced plasma wastage. Also, plasma separated from whole blood and stored at 4 °C for 21 days, and referred to as liquid plasma, retains close to 90% coagulation factor activity, and is the primary source of plasma in many European DCR strategies. Reconstituted lyophilized plasma (LP) is another source of this blood component that may be used immediately for a recipient of any blood type because of dilution and neutralization of anti-A and anti-B hemagglutinins. LP, which contains coagulation factor levels equivalent to FFP, has been used by the French Army since 1994. Presently, LP is utilized by medics of the Israeli Defense Force for resuscitation of combat casualties in hemorrhagic shock, and previously LP was carried for a similar purpose by U.S. Special Operations Forces in Afghanistan
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