Introduction
centrosomes are the microtubule organizing centers(MTOCs) of most animal cells and play a critical role in mitotic spindle orientation. The centrosome consists of a pair of centrioles,namely mother and daughter centrioles, embedded in the peri centriolar matrix(POM), The PCM contain y -tubulin ringcomplexes(y TuROs), which play important roles in nucleating, anchoring, and positioning microtubules. Centrioles are characterized by a nine-fold radical symmetry of microtubules(MTs) and also function as basal bodies for the formation of cilia and flagella. The mother centriole harbors subdistal and distal appendages that play important roles in anchoring MTs and in docking centrioles to the membrane during flagellum or cilium formation.