The key advantages of utilizing human tumor xenografts are able to outweigh the disadvantages.
Xenografts have been successful because:
They represent the complexity of genetic and epigenetic abnormalities found commonly in human population,
They can assist in the creation of personalized molecular therapies,
Multiple therapies can be tried on a single tumor biopsy,
The stroma from the human tumor microenvironment can be incorporated in to the xenograft to more completely imitate the human tumor microenvironment.