In summary, our results demonstrate that Nitric oxide, generated from 0.1 mM SNP, enhances resistance of ripening mango to postharvest anthracnose caused by C. gloeosporioides. The enhancement of resistance against fungal pathogens may be linked to activation of defense responses as well as delay of ripening. Details on the mechanisms of Nitric oxide-mediated resistance in ripening warrant further investigation. We suggest that application of Nitric oxide could be a potential strategy for preventing disease development and extending the shelf life of harvested mango and other crops. Future postharvest uses of Nitric oxide might be facilitated by development of alternative formulations and application technologies (e.g. nanotechnology) (Singh et al., 2013).