We also observed a
28% decrease in the relative risk of advanced lesions. All of the trials
included in this meta-analysis involved a higher-dose aspirin arm
( ≥ 300 mg/d). In comparisons of higher-dose aspirin vs placebo, there
was a 15% non – statistically signifi cant decrease in the relative risk of
any adenoma; however, the corresponding absolute risk reduction of
5.7% was statistically signifi cant.