The Knodell system evaluated separately, each of four histopathological axes
(periportal ± bridging necrosis, intralobular degeneration/focal necrosis, portal inflammation, and “fibrosis”), and assigned a “numerical” score to each. To enhance the discriminant potential of the system, the difference between mild and serious disease was accentuated by eliminating the “number” (category) 2 from the scoring system for each histopathological axis. By omitting “2”,