Scientists evaluated five large studies comprising more than one million participants to develop a down to determine carotenoids eaten in the form of fruits and vegetables. Lead study author Dr. Alberto Ascherio noted, "understanding the impact of food consumption on Amyotrophic lateral sclerosis(ALS) development is important. Our study is one of the largest to date to examine the role of dietary antioxidants in preventing ALS".
A total of 1,093 cases of ALS were identified across the cohort of subjects. The team found that those with the highest intake of carotenoids from any source had the lowest risk of developing ALS. They also determined that individuals who consumed more carotenoids in their diets were more likely to exercise, have an advanced degree, have higher vitamin C consumption, and take vitamin C and E supplements. Participants with the highest dietary consumption of beta-carotene and lutein, most commonly found in dark green vegetables had a reduced risk of developing ALS.
Interestingly, the researchers found that diets high in lycopene, beta-cryptoxanthin, and vitamin C did not reduce disease incidence, and long-term vitamin C supplement intake was also not associated with lower ALS risk. Dr. Ascherio concluded "Our findings suggest that consuming carotenoid-rich foods may help prevent or delay the onset of ALS." This study acts to support a large volume of prior works that reinforce the critical importance of a natural food diet consisting largely of fruits and vegetables to thwart diseases ranging from cancer and diabetes, to Alzheimer's disease and ALS.