Clinicians are universally aware of the common occurrence of fever caused by drugs, although reliable data on incidence are not available. Fever can be the sole manifestation of an adverse drug reaction in 3 to 5 percent of cases [1,2]. The risk of developing drug fever increases with the number of drugs prescribed, especially in older adult patients. Individuals with active HIV infection also appear to have an increased susceptibility to drug reactions of all types, including fever [3-5].