One possible way to circumvent the problem of bioavailability
for skin disorders is to apply resveratrol topically to the skin. This
would allow resveratrol to come into direct contact with the area
of interest, without the side effects associated with systemic
metabolism. Currently, several topical formulations of resveratrol
are being developed. Hung et al. have studied several different
solutions and hydrogel patches as delivery routes for resveratrol