A new diplurid genus and species is described from northeast India based on a single female specimen from Jampui hills. Orientothele gen. nov. is placed in the subfamily Diplurinae based on presence of one row of teeth on chelicerae. The new genus and species can be diagnosed from most diplurid genera in lacking lyra on prolateral face of maxilla, paired claw with one row of teeth, maxilla with numerous cuspules, scopulae absent on al legs and spermathecae consists of two elongate stalks with bulbous receptacles at their tips which are bent inwards. Ischnothele indicola Tikader, 1969 is here treated as incertae sedis with regards to its generic placement in light of the discovery of Orientothele gen. nov.