Despite the increasing reported applications of AGS for municipal and industrial wastewater, textile wastewater treatment with this technology has scarcely been reported [14]. Thus, the objective of this work was to assess the applicability of the novel AGS technology in SBR as an alternative to the conventional flocculent activated sludge SBR technology for dye-laden textile wastewater treatment. For that, the performance of two anaerobic/aerobic SBR systems,one with activated sludge flocs and the other with aerobic granules,was evaluated in terms of chemical oxygen demand (COD) and color removal efficiencies in the treatment of a simulated textile wastewater. To our knowledge, this is the first time that such a comparison is performed. In parallel to color and COD removal profiles, the potential detoxification of the simulated textile wastewater during SBR operation was also examined by using yeast-based assays[15,16] with the eukaryotic model Saccharomyces cerevisiae. This is a simple, animal-alternative and relatively inexpensive experimental test system that can provide a fast preview of the potential toxicity of chemicals/effluents meaningful for other eukaryotes[15–17].