Experiments recorded 85% of maximum cadmium (II) removal under optimum operation. The optimum parameters for cadmium (II) removal were 0.5 g of Pleurotus ostreatus biosorbent concentration, initial pH of pH 6, 10 minutes of contact time and 10 mg/L initial cadmium (II) concentration. The cadmium removal in industrial wastewater showed lower percentage of cadmium (II) removal if compared to synthetic solution. This is because there are competition of others heavy metals and low pH of industrial wastewater is also not represented the optimum operation condition. Removal of heavy metals by Pleurotus ostreatus biosorbent is in-line with the alternative sustainable technology development for wastewater purification system.