Evaluation of the antibacterial activity of crude extracts from different parts (root, stem, leaf) of Carissa carandas (Apocynaceae) Linn. was carried out in the present investigation. Extraction was done by using polar (Water and Methanol) and Non-polar (Petroleum ether) solvents and were screened by ‘Disc Diffusion Assay’ against 3 Gram negative (E.coli, K.pneumoniae and A.tumifaciens) and 2 Gram positive (S.aureus and B.subtilis) bacteria. Minimum inhibitory concentration, Minimum bactericidal concentration and Total activity were recorded. Mean and Standard deviation also has been calculated. B.subtilis and A.tumifaciens found to be most susceptible organism followed by E.coli. Leaf and stem crude extracts, showed the best activity against B.subtilis [pet. ether (IZ=23mm), methanolic (IZ =22.5) & water (IZ =22.5)] and [pet ether (IZ =20mm), methanolic (IZ=18mm) & water (IZ =18mm)]. The range of MIC & MBC was found to be 1.25-0.078 mg/ml & 0.625-0.039 mg/ml respectively. Results indicate that almost all the tested crude extracts have potent antibacterial activity.