O'Mahony and Donnelly (2007) argue that, to respond to the needs of refugee women, nurses must be able to recognize the complexity of their individual experi- ences and acquire a more meaningful understanding of the social, cultural, economic, and political aspects of their lives and their subsequent health effects. In this article, we build on this argument and attempt to demonstrate that intersectionality can be used to better understand the experiences of HIV-positive refugee women in the context of pregnancy and the impact of these experiences on their health and well- being. This alternative framework is important to nursing practice because it shifts the focus away from a biomedical approach onto the needs of refugee women who face significant challenges in navigating complex socioeconomic, cultural, political, and institutional structures and whose pregnancy is simultaneously constructed as natural and disease-like through interactions with health care providers. We hope to illustrate that intersectionality is a useful framework to shed light on various influences that may be contributing to health disparities and barriers that affect the health and well-being of HIV-positive refugee women in the context of pregnancy.