It is generally agreed that classic liposomes have little or no value as carriers for transdermal drug delivery. Deep skin
penetration is prevented and the vesicles remain confined to the upper layer of the SC. Especially designed carrier vesicles able to allow transdermal delivery are recent approaches in modulating delivery through the skin. Several procedures produce liposomes able to deliver molecules into the deeper layers and across the skin, showing better stability, high drug entrapment efficiency or delivery modulation into/through the skin [152]. Table 3 summarizes some examples of special vesicular systems for transdermal delivery.