Mercury (Hg) status can be assessed by hair or blood biomarkers [1]. Humans who consume certain types of fish may have higher mercury concentrations in their system [2]. Methyl mercury is readily absorbed from the gut into the bloodstream, where it binds to red blood cells [3]. Previous analytical methods for measuring blood mercury tested only red blood cells; however whole blood methods are now gaining ground [4]. Use of whole blood reduces sample preparation time and elimi-nates uncertainty relating to cell number. Centrifugation and separation of red blood cells also present an oppor-tunity for analyte loss and increases the overall uncer-tainty in measurement. Reducing the time and steps in-volved in sample preparation facilitates measurement of mercury in clinical settings.