Most of the studies initilially showed that Doxo upregulates cardiac autophagy and contributes to Doxo-dependent cardiotoxicity. By contrast, others have reported that activation of autophagy protects against Doxo cardiotoxicity. However, recent reports show that Doxo impaired autophagy. A recent work by Hill’s group supports these findings, showing that Doxo blocks lysosomal acidification, thus disrupting the autophagy flux