Discussion
Given current concerns surrounding conventional antidepressant therapy and suicidal, which led to the boxed warning in labeling, it is conceivable that use of “natural” antidepressant therapies will rise.Recently available data suggesting that some antidepressants may be associated with teratogenicity may also increase the use of CAM treatments for treating perinatal depression, despite the fact that no systematic information exists regarding the safety of Hypericum or SAM-e use during pregnancy.the objective of this systematic review was to determine whether the scientific evidence regarding antidepressant efficacy actually justifies wider use.