4. Conclusion
The present study demonstrates the antioxidant, anticancer and
DNA protective effects of white tea (C. sinensis). White tea extract
exhibited a strong antioxidant activity in the five assays carried
out, i.e., the FRAP, DPPH, nitric oxide, superoxide anion and hydroxyl
radical scavenging assays. The high antioxidant activities correlated
significantly to their phenolic content. Pre-treatment of 3T3-L1 cells
with the extract protected against H2O2-induced DNA damage.
The tea extracts also showed high anti-proliferative activity
against HT-29 cells, without being toxic to normal fibroblasts.
The extract inhibited HT-29 colon cancer cells by the death receptor
and mitochondrial apoptotic pathways as demonstrated by
increased expression levels of caspases-3/7, -8 and -9.
In conclusion, white tea extracts show potential as chemotherapeutic
agents. Regular consumption of white tea could maintain
good health and protect the body against disease.
4. Conclusion
The present study demonstrates the antioxidant, anticancer and
DNA protective effects of white tea (C. sinensis). White tea extract
exhibited a strong antioxidant activity in the five assays carried
out, i.e., the FRAP, DPPH, nitric oxide, superoxide anion and hydroxyl
radical scavenging assays. The high antioxidant activities correlated
significantly to their phenolic content. Pre-treatment of 3T3-L1 cells
with the extract protected against H2O2-induced DNA damage.
The tea extracts also showed high anti-proliferative activity
against HT-29 cells, without being toxic to normal fibroblasts.
The extract inhibited HT-29 colon cancer cells by the death receptor
and mitochondrial apoptotic pathways as demonstrated by
increased expression levels of caspases-3/7, -8 and -9.
In conclusion, white tea extracts show potential as chemotherapeutic
agents. Regular consumption of white tea could maintain
good health and protect the body against disease.
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