In this paper, we found that sulphur-containing compounds of
durian activate the thermogenesis-inducing receptors TRPA1 and
TRPV1. In addition, we showed that durian pulp contains a sufficient
amount of sulphides to evoke TRPA1 and/or TRPV1 activation.
Moreover, the essential oil of durian activated TRPA1, and the main
agonist was DEDS. From these results, we consider that the hyperthermic
effect of durian is produced by sulphide-induced TRPA1
activation.