In conclusion, the present study has shown for the first time that
long-term cocoa supplementation can reduce AT inflammation in HFfed mice by down-regulating NF- κB target gene expression and modulating eicosanoid metabolism. Although further studies are
needed, our results suggest that dietary cocoa powder can exert antiinflammatory activity in part by modulating gut barrier function and metabolic endotoxemia. These results provide a putative mechanism of action which is congruent with the reported low bioavailability of
cocoa polyphenols and high fiber content in cocoa powder