The yield increase over control due to single effect of NPK and S are shown in Table 2. Nitrogen application up to 120 kg/ha increased yield significantly and thereafter decreased. Application of 120 kg N/ha increased yield of bitter gourd by 86% in 2010 and 54% in 2011 over the control. Yield of bitter gourd also increased significantly due to application of P up to 40 kg/ha and further increase in P decreased the yield. Fertilization with K also followed the same response on yield (Table 2). The yield varied from 14.07 to 18.56 t/ha in 2010 and 13.65 to 17.85 t/ha in 2011 due to different levels of K application. Yield of bitter gourd also increased with the increase rate of S up to 30 kg/ha and then decreased. The result indicates that the yield increased with the increase of N, P, K, and S application up to certain limit. Effect of N and P was distinct in comparison to K and S. Table