Despite the lack of prospective randomized con-trol trials, the MAD has also demonstrated substantial
efficacy in controlling seizures. Of the patients who
have been studied on the MAD, 45% have demon-strated 50%–90% seizure reduction and 28% have
.90% seizure reduction. Similar results have been
reported in two retrospective studies of the LGIT,
with 38%–73% of patients achieving .50% seizure
reduction.
70,71
The best candidates for the MAD tend
to be adults and adolescents, for whom compliance
on the LCFA and MCT diets is an issue.
64
This is
because the food consumed on the MAD is similar
to that being consumed by peers. The same can be
said about the LGIT, which in addition can be con-sidered for patients who find the other 3 high-fat diets
unpalatable.