Around 150 BC, Mesopotamia was under the control of the Parthians. Mesopotamia became a battleground between the Romans and Parthians, with parts of Mesopotamia coming under ephemeral Roman control. In AD 226, it fell to the Sassanid Persians and remained under Persian rule until the 7th-century Arab Islamic conquest of the Sassanid Empire. A number of primarily neo Assyrian and Christian native Mesopotamian states existed between the 1st century BC and 3rd century AD, including Adiabene, Osroene, and Hatra.