TEM photograph for F5 in Fig. 3B showed well formed vesicles surrounded with thin dark layer, this may be referred to presence of solubilized CUR in this layer which mainly composed of high concentration of surfactants with a high solvent capacity while the inner part is transparent as for the presence of MCT oil with a low solvent capacity towards CUR. These findings also support our suggestion about the effect of surfactants in decreasing ZP value for such formulation