Silk sericin and silk fibroin are extract from silk cocoon. Silk sericin-collagen/silk fibroin scaffolds at varied blending ratios (i.e. 100/0, 70/30, 50/50, 30/70 and 0/100) were prepared by freeze-drying method. These scaffolds were characterized for their morphology, water swelling, weight loss, mechanical properties and in vitro degradation.