Evidence supporting the use of PPIs in peptic ulcer disease
(PUD) includes its ability to offer suppression of acid secretion,
ulcer healing, and symptom relief that is superior to suppression
that is associated with other antisecretory therapies, and
has led to their role as the mainstay of therapy (level of evidence
A).9 Much of the morbidity and mortality arising from
PUD arises from rebleeding. Patients with bleeding peptic
ulcers who are treated with a PPI have demonstrated a decrease
in the need for transfusions or surgery and a reduction in length