The results indicated that the precipitation of andrographolide from
A. paniculata extract is successfully performed using SAS process. The
SAS process produced uniform andrographolide crystals of small size.
The operating pressure, temperature and CO2 flow rate are important
variables affecting the precipitation process. We found that particle
size decreases with increasing pressure in the range of 10–24 MPa,
decreasing temperature in the range of 308–328 K and increasing CO2