Normally, most of these methods are focused on specific
groups of residues, not being suitable for wide-scope multiresidue
analysis able to cover different classes of residues
and contaminants. However, the use of wide-scope methods
inherently involves the need for generic extraction procedures,
and this strategy shortens the possibilities for cleanup
steps [26, 27], in order to minimise analyte losses.
Nevertheless, the lack of selectivity in sample preparation
can be compensated by selectivity/sensitivity in instrumental
analysis. Although in terms of sensitivity, the use of GC
or LC coupled to triple quadrupole (QqQ) is usually preferred,
and the number of compounds that can be acquired
by these techniques in one run is limited [28, 29].