Twenty-two subjects with a diagnosis of bipolar disorder (nine men and 13 women) were included in the study. Two other subjects who provided consent were not included in the study because of missing data (i.e., no baseline clinical assessment or no postbaseline assessments.) The mean age at first diagnosis was 24 years (SD=7, range=10–44; age at first diagnosis data were not available for three subjects). The mean age at entry, final clozapine dose level, and clinical ratings over the course of the trial are presented in Table 1.