(C) Crystal structure of the PCNA (green) and FEN-1 (yellow) complex. Lineage-specific residues on the PCNA structure are colored in red. A zoom in on th
e
structures reveals a putative interaction between two
b
sheets, one within PCNA and another within FEN-1. This interaction may be altered through a second
interaction between the PCNA
b
sheet and a lineage-specic change from glutamine to histidine within PCNA. Distance measurements between pairs of atoms are
marked in black. PDB accession number: 1UL1.
See also
Table S3
and
Figure S3