Maternal side effects are few as long as these
agents are used for a short time only, and as long as
no contraindicating conditions are present
(gastro intestinal ulcers, bronchial asthma, coronary
heart disease). Indomethacin crosses the placenta
and can cause serious fetal complications if it is used
for more than 48 hours or after GW 32; these range
from a reduction of the volume of amniotic fluid to
persistent fetal anuria and, in up to 50% of fetuses