Finally, we have witnessed substantial progress in both human genetics and animal models of hypertension, but have seen few truly translational studies. It appears that both approaches have been developed in parallel with little focus on informing each other. This will almost certainly change in the next few years, but probably not necessarily in the direction “animal to man” but more likely in the direction “man to animal”. The highly sophisticated tools that are now available for human genomic studies have led to the identification of numerous causative genes and genetic loci that require detailed studies of function in experimental models.