Signaling pathway in cancer
In healthy cells, complex signaling networks continually process input cues from the extracellular and intracellular environment in order to determine cell fate, such as whether or not to grow, proliferate, migrate, or die. This “signal-cue-response” model explains how input cues stimulate the signaling network to govern cell behavior(1). As we continue to understand these signaling networks, it is becoming increasingly clear that the pathways themselves do not follow a static, linear progression, but rather are highly dynamic, multivariate, and can adapt to differing inputs over time. Therefore, genetic mutations that disrupt or change the network nodes may lead to differential input processing resulting in profound effects on cell fate, such as unregulated cell proliferation and ultimately in cancer. - See more at: http://www.cellsignal.com/contents/science/cancer-research/cancer-research#sthash.u3uvaMko.dpuf