To transform a chaotic system of discreet preparation and training experiences into a coherent, aligned, and logical system of continuous and progressive training and support throughout teachers’ career with the 5E-Inquiry, STEM, and the Problem-Based Instructional Methods. For this 3-instructional method specifically, two lower secondary education schools of 212 students at the 7th grade level in 6 classes that it consisted of sample in this study. Comparisons between the effectiveness of problem-based learning (PBL), the 5E-Inquiry Model, and STEM instructional approaches in developing students’ learning knowledge and examined whether PBL, 5E, and STEM were differentially effective with students demonstrating same level of each four lesson plans for administering heterogeneous and homogeneous substances for each two classes from each school. Research procedure was designed to assessment students’ perceptions of their satisfaction on the 3-instructional method were compared. Statistically significant was differentiated between pretest and posttest technique assessments on each instructional method. Associations between students’ learning achievements of each their instructional model and students’ attitudes were assessed with the Learning Achievement Test and the Test Of Science-Related Attitudes (TOSRA) were found, relationships’ significantly. Overall on these findings, suggestions that STEM education must all increase students’ capacity to support high-quality math and science instruction at all points along the teacher-training continuum. The 5E inquiry learning model indicates that starts by posing questions, problems rather than simply presenting established facts or portraying a smooth path to students’ knowledge. The PBL can be considered a constructivist approach to instruction, emphasizing collaborative and self-directed learning and being supported by flexible teacher scaffolding.