Conclusions: PhysalinAinducedapoptoticcelldeathviap53-Noxa-mediatedROSgeneration,and
autophagy playedaprotectiveroleagainstapoptosisthroughup-regulatingthep38-NF-κB survival
pathwayinA375-S2cells.TheseresultsstatedthepossibilitythatphysalinAwouldbeapotentialagent
for thetreatmentofmelanomainthefuture