Whereas these in vitro data demonstrate several mechanisms of
protection common to both HbAS and HbAC, the results of the
present study, together with other in vivo findings,22,23,25 suggest
that the effects of HbS and HbC on the risk for malaria may differ.
Although not completely transferable to the situation in uncomplicated
malaria, 2 clinical studies on severe malaria support the
hypothesis of a different protective effect of HbS and HbC traits.