No consensus on diagnostic criteria or diagnostic tests has been established.
The presence of a disease that can cause MHE; cirrhotic patients and/or the presence of a transjugular intrahepatic portosystemic shunt (TIPS).
Without clinical signs of encephalopathy (i.e., normal mental status on clinical examination).
Disturbed sleep pattern.
Memory impairment.
Poor performance in psychometric tests.
Affects an estimated 60% (50% to 80%) of patients with cirrhosis.
Cerebral dysfunction has a variable impact on patients' daily living.
Exclusion of concomitant neurological disorders.