ANTIBIOTIC THERAPY
The authors recognize that the recommendations for the majority e of antibiotic regimens have been based on consensus, and that the t optimal treatment for staphylococcal endocarditis and the emoirical a treatment are still under debate
Table
Changes Established in Antibiotic Therapy
Restrictions in aminoglycoside therapy:
Not recommended for native valve Staphylococcus aureus endocarditis
Administration in a single daily dose
Two weeks for enterococci and penicillin-resistant streptococci
Alternative regimen for Enterococcus endocarditis: ampicillin and ceftriaxone
New cutoffs to define penicillin-susceptible (MICso125 mglu, intermediate resistant (MIC 0.25-2 mg/L), and resistant (MIC 4 mg/L) streptococci
Nmurlinfls to define penicillin-susceptible (MIC s006 mgL), intermediate