Holistic. The history of science is a story par excellence of splitting and analyzing everything under the sun to maximize our knowledge of the parts and pieces that constitute any entity we deem worthy of study. The contrasting complement to analysis is synthesis. Systems approaches to inquiry tend to emphasise the latter, even though a systems analysis may be part of the process of inquiry to, as the nursery rhyme goes, “put Humpty-Dumpty back together again.” Noteworthy is the point in passing that dissecting the corpse and making synthetic inferences as to its functional and organic hole-ness may be informative, but these forms of inquiry lack the vital forces and flows that make the study of human organizations confirmatory of what may be known. We must study in vivo human organizations, typically being part of them, given they exist at a more macro level of description that the individual. Synthesizing research processes are integrative and holistic, in that they foster more macro level descriptions of knowledge. To seek open knowledge at the global level of the organization is an ultimate challenge that must be recognized as such,because it will likely take further developments this century to advance the technologies necessary to make available to organizations ongoing monitoring of their global activities and flows of communications, resources,and activities,thus creating the favorable conditions for detecting the emergence of open knowledge.