Glucosamine
sulfate is a naturally occurring substance found in
human cartilage and a precursor for glycosaminoglycans
(GAGs).Acombinationof supplements, glucosamineandchondroitin
sulfate,wasshownin the Glucosamine/Chondroitin Arthritis
Intervention Trial to aid moderate to severe osteoarthritic
knee pain.1
Open-angle glaucoma affects more than 2 million individuals
in the United States, and this number continues to increase
owing to the rapid aging of the US population.2 Normal
aqueous outflowof the eye is regulated by the content of
GAGs.3 Researchers postulate that excessive deposits of GAG
in the trabecular meshwork restrict outflow. Another theory
suggests that increased release ofGAGinto the aqueous causes
an osmotic effect, drawing morewater into the anterior chamber,
thus causing swelling, a decrease in pore size, and eventual
increased resistance to outflow.3 Either of these proposed
mechanisms could lead to an increased thickness of the
pore lining and/or decreased outflow, resulting inincreased intraocular
pressure (IOP).Excessive glucosaminemoleculesmay
similarly elevate IOP.
In a small retrospective clinical study,we examine the relationship
between glucosamine supplementation and increased
IOP in patients with glaucoma who supplement with
glucosamine.
Glucosaminesulfate is a naturally occurring substance found inhuman cartilage and a precursor for glycosaminoglycans(GAGs).Acombinationof supplements, glucosamineandchondroitinsulfate,wasshownin the Glucosamine/Chondroitin ArthritisIntervention Trial to aid moderate to severe osteoarthriticknee pain.1Open-angle glaucoma affects more than 2 million individualsin the United States, and this number continues to increaseowing to the rapid aging of the US population.2 Normalaqueous outflowof the eye is regulated by the content ofGAGs.3 Researchers postulate that excessive deposits of GAGin the trabecular meshwork restrict outflow. Another theorysuggests that increased release ofGAGinto the aqueous causesan osmotic effect, drawing morewater into the anterior chamber,thus causing swelling, a decrease in pore size, and eventualincreased resistance to outflow.3 Either of these proposedmechanisms could lead to an increased thickness of thepore lining and/or decreased outflow, resulting inincreased intraocularpressure (IOP).Excessive glucosaminemoleculesmaysimilarly elevate IOP.In a small retrospective clinical study,we examine the relationshipbetween glucosamine supplementation and increasedIOP in patients with glaucoma who supplement withglucosamine.
การแปล กรุณารอสักครู่..
