Randomized trials testing models of service delivery have shown that treatment of depression in later life in primary care settings can lead to remission of major depression, reduced symptoms of depression, improved quality of life, and a reduction in functional impairment. For example, Improving Mood-Promoting Accessto Collaborative Treatment (IMPACT), a collaborative care program that involved a nurse or psychologist in the primary care office to support management by the primary care physician, was associated with improvements in depressive symptoms, functioning, and quality of life.