Note the differenttransport directions related to the cytosol (cyt, light yellow) of the respective cells. (A) In[11_TD$DIFF]Escherichia coli, uptake of free FAs(FFA) is mediated by theb-barrel protein FadL in the outer membrane (OM) and FadD, a fatty-acyl CoA synthetase (FACS) atthe cytosolic face of the plasma membrane (PM), which couples FFAs as thioesters to coenzyme A (CoA).