Yadav and Sarasija (2009)reported a sensitive RP-HPLC–UV method for the determination of
curcumin but system suitability and stability studies were not performed. Recently, a stability indicating HPLC–UV method was reported by Gugulothu and Patravale (2012) for determination of curcumin and celecoxib in nanoparticle formulation. The result showed that curcumin in solution was not stable and degraded after 1 h of stress studies.Curcumionoids are polyphenols and decomposed when exposed to high temperature (Schieffer, 2002).